Synergy Between Tissue Factor and Exogenous Factor XIa in Initiating Coagulation
نویسندگان
چکیده
منابع مشابه
Synergy Between Tissue Factor and Exogenous Factor XIa in Initiating Coagulation.
OBJECTIVE Recent evidence suggests involvement of coagulation factor XIa (FXIa) in thrombotic event development. This study was conducted to explore possible synergies between tissue factor (TF) and exogenous FXIa (E-FXIa) in thrombin generation. APPROACH AND RESULTS In thrombin generation assays, for increasing concentrations of E-FXIa with low, but not with high TF concentrations, peak thro...
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We report here the effect of activated human platelets on the activation of human factor IX by human factor XIa. Factor IXa formed during activation was determined via its ability to activate bovine factor X. To increase sensitivity, phospholipids and bovine factor VIIIa were present in the assay. The kinetic parameters of the factor IX activation were determined in the presence of 10 mmol/L Ca...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2016
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.116.308186